1/8/2023 0 Comments Ancora pain recoveryTherefore, this systematic review and meta-analysis aim to fill the gap by evaluating the efficacy of combining OS and NNS in different scenarios of comparison and exploring the safety of this intervention method preliminarily. The superiority of the combination to various single interventions was also barely covered. ![]() However, they may have neglected the variations in effectiveness and safety under different painful procedures. Previous reviews or meta-analyses have preliminarily evaluated the combined effects of NNS and sucrose. It has been common knowledge that OS and NNS could separately alleviated pain in neonates. Among which the combined effects of NNS and sucrose were tested by numerous prospective randomized trials. For example, combined effects of music and touch, sucking, breast milk and tucking, music and sucrose, oral sucrose (OS) and nonnutritive sucking (NNS), etc. Ĭombined therapy was assumed to be more efficient in pain relief than single interventions and has been investigated frequently in recent studies. An updated research revealed the use rate of nonpharmacologic interventions tended to be higher than pharmacologic interventions. On the other hand, nonpharmacological methods have been developed in recent years to help reduce multiple bedside interruptions and have been considered safe and effective in pain management. In addition, it remains unclear whether the administration of anesthetics is safe thus, selective use of pharmacological treatment is recommended, such as opioids, non-opioids, and other anesthetics. Even in a developed country like Canada, analgesic interventions were not offered in almost half of painful procedures, according to an epidemiology study. In some developing countries, most infants were not provided any analgesic intervention during painful procedures. Newborns, especially preterm infants, are frequently subjected to painful procedures, repeated painful and stressful stimuli may develop clinical, physiologic and psychologic sequelae in the short or long term. Neonatal Pain Agitation and Sedation Scale WMD, R: premature infant pain profile-revised NIPS, The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: Our paper is supported by Project of Sichuan Provincial Health Commission in 2014 (NO: 140108). Received: JAccepted: ApPublished: May 6, 2022Ĭopyright: © 2022 Li et al. PLoS ONE 17(5):Įditor: Girish Chandra Bhatt, All India Institute of Medical Science - Bhopal, INDIA (2022) Efficacy and safety of combined oral sucrose and nonnutritive sucking in pain management for infants: A systematic review and meta-analysis. Citation: Li Q, Tan X, Li X, Tang W, Mei L, Cheng G, et al.
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